2021-06-12 11:22:25
C лессронга про утечку коммент:
Donald Gislason2h
1
The recent article by Steven Quay & Richard Muller in the Wall Street Journal attempts to bring the issue to a head by simplifying it down to two main points:
(1) The double CGG codons in the SARS2 furin cleavage site were deliberately designed by the 11 or 12 researchers who have created chimeric viruses as an unmistakable 'marker' for lab-made viruses so that you could always tell which future mutations evolved from a lab virus and which were naturally evolved. SARS2 has these tell-tale double CGG codons in its furin cleavage site, ergo it's lab-made.
(2) Natural evolution, of the type displayed by SARS1 & MERS, involves a long series of "run-up" mutations (tries and fails) both in the bat & in the intermediary animals (palm civets, dromedary camels). They also had a similar series of immediate "follow-on" mutations in a race for "optimization" of infectivity once the virus broke out in humans. No evidence has been found for SARS2 displaying either the run-up or the follow-on, ergo it's unlikely to be naturally evolved.
I would welcome hearing of competent commentary that directly refutes these two arguments. Maybe an actual gene-splitting researcher might say "Nah, we did it that way because it was easier, or because it was cheaper. We didn't do it to create a marker." Or maybe "We kept using the same codons as previous researchers had used merely in order to eliminate one factor of variability and make it easier to analyze our results." Something like that.
Or, "The way SARS1 and MERS developed is only one of the possible ways for viruses to evolve. There are many other ways. That they didn't have a run-up and follow-on of mutations is in no way indicative."
If anyone finds articles addressing these arguments head-on, I would appreciate hearing about it.
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