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Electrogastrography for diagnosis of early-stage Parkinson’s d | Gastroenterology

Electrogastrography for diagnosis of early-stage Parkinson’s disease


Introduction: Patients with Parkinson’s disease (PD) often present with gastric symptoms. Electrogastrography (EGG) can noninvasively assess gastric electric activity and may be useful for early PD diagnosis. The present study aimed to compare the efficacy of EGG in early PD diagnosis with those of 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy and odor stick identification test – Japanese version (OSIT-J).

Methods: Thirty-seven untreated PD patients (mean age ± SD, 66 ± 8 years; disease duration < 3 years) and 20 healthy control subjects (68 ± 6.9 years) were recruited. EGG and OSIT-J were performed in both groups, and MIBG scintigraphy in the PD group. EGG parameters were assessed in the preprandial and early and late postprandial segments using power spectrum analysis.

Results: Irregular EGG waves were observed in PD patients. The preprandial instability coefficient of dominant frequency (ICDF), an index of EGG irregularity, in PD patients (9.5% 6.3%) was higher than that in controls (3.9% 3.9%, p = 0.00005). The OSIT-J score was also lower in PD patients (4.6 3.3) than in controls (7.7 3.3, p = 0.006). In receiver operating characteristics analyses, the areas under the curves of preprandial ICDF and OSIT-J were 0.83 and 0.72, respectively. The sensitivities of preprandial ICDF and MIBG (delayed-phase) scintigraphy were 73% and 70%, respectively.

Conclusions: Early and untreated PD patients showed irregular EGG waves and high ICDF. EGG showed better accuracy than the olfactory test for early PD diagnosis and similar sensitivity to MIBG scintigraphy.

См.: https://GastroScan.ru/literature/authors/13610

Рисунок. Raw data and dominant frequency in electrogastrography of patients with Parkinson’s disease and healthy subjects. Four recording electrodes and one reference electrode were placed on abdominal skin. (A) Regular, preprandial gastric slow waves becoming irregular during the early postprandial period, but returned to regular during late postprandial in a healthy subject. (B) Irregular gastric waves in preprandial and early and late ostprandial periods in a patient with Parkinson’s disease. (C) Gray squares and black circles indicate means of dominant frequency in healthy controls and patients with Parkinson’s disease, respectively. Vertical bars indicate standard errors.